Tenecteplase vs Alteplase before Endovascular Therapy in Basilar Artery Occlusion

F Alemseged; FC Ng; C Williams; V Puetz; G Boulouis; TJ Kleinig; A Rocco; TY Wu; D Shah; F Arba; D Kaiser; F Di Giuliano; A Morotti; F Sallustio; HM Dewey; P Bailey; B O'Brien; G Sharma; S Bush; R Dowling; M Diomedi; L Churilov; B Yan; MW Parsons; SM Davis; PJ Mitchell; N Yassi; BCV Campbell

Conference Proceedings

Tenecteplase vs Alteplase before Endovascular Therapy in Basilar Artery Occlusion

F Alemseged, FC Ng, C Williams, V Puetz, G Boulouis, TJ Kleinig, A Rocco, TY Wu, D Shah, F Arba, D Kaiser, F Di Giuliano, A Morotti, F Sallustio, HM Dewey, P Bailey, B O'Brien, G Sharma, S Bush, R Dowling Show all

Neurology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2021

DOI: 10.1212/WNL.0000000000011520

Abstract

ObjectiveTo investigate the efficacy of tenecteplase (TNK), a genetically modified variant of alteplase with greater fibrin specificity and longer half-life than alteplase, prior to endovascular thrombectomy (EVT) in patients with basilar artery occlusion (BAO).MethodsTo determine whether TNK is associated with better reperfusion rates than alteplase prior to EVT in BAO, clinical and procedural data of consecutive patients with BAO from the Basilar Artery Treatment and Management (BATMAN) registry and the Tenecteplase vs Alteplase before Endovascular Therapy for Ischemic Stroke (EXTEND-IA TNK) trial were retrospectively analyzed. Reperfusion >50% or absence of retrievable thrombus at the tim..

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University of Melbourne Researchers

Fana Alemseged Author

Richard Dowling Author

Leonid Churilov Author

Bernard Yan Author

Related Projects (1)

OPTIMIZING STROKE THERAPY - ADVANCED BRAIN IMAGING AND REPERFUSION THERAPIES

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

F. Alemseged, F. Ng, C. Williams, V. Puetz, G. Boulouis, T.J. Kleinig, A. Rocco, T.Y. Wu, D. Shah, F. Arba, D. Kaiser, F. Di Giuliano, A. Morotti, F. Sallustio, H.M. Dewey, P. Bailey, B. O'Brien, G. Sharma, S. Bush, R.J. Dowling, M. Diomedi, L. Churilov, B. Yan, and M.W. Parsons report no disclosures relevant to the manuscript. S.M. Davis reports Medical Advisory Board relationship with Medtronic and Boehringer Ingelheim. Peter J. Mitchell and Nawaf Yassi report no disclosures relevant to the manuscript. B.C.V. Campbell reports research support from the National Health and Medical Research Council of Australia (GNT1043242, GNT1111972, GNT1113352) and National Heart Foundation (100782). Go to Neurology.org/N for full disclosures.